Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 3
Metformin time-course comparison of experimental data and model simulations for tissues.
Plasma (A) following a single 1000mg PO dose in humans [36] and simulations for plasma (B), red blood cells (C), and urine (D) following a single 500mg PO dose in humans [20]. The red marks represent the experimental data’s concentration-time profiles, where the red error bars represent the standard deviation, and the blue lines represent the model simulations.