Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 1
Metformin pharmacokinetics in major compartments of metformin action.
Venous plasma (A), portal vein (B), small intestine (C), liver (D), kidney (E), heart (F), muscle (G), adipose (H), brain (I), feces (J) and urine (K) following a single PO 50 mg/kg dose in mice. The red marks represent the experimental data’s concentration-time profiles with error bars representing standard deviation [1] and the blue lines represent the model simulations.