Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions
Fig 6
Bivalent harvesting function of the BSG Ig-I domain for protons and l-lactate anions.
(A) In the absence of the extracellular BSG Ig-I domain, the environmental concentrations of l-lactate and protons determine transport. (B) The presence of the Ig-I domain creates a microenvironment and increases the local concentration of the substrate and protons at the MCT entry site driving accumulation in the cell.