Lung gene expression and single cell analyses reveal two subsets of idiopathic pulmonary fibrosis (IPF) patients associated with different pathogenic mechanisms
Fig 3
Gene signature scores for non-hematopoietic cell populations in GSE47460 (Kaminski-LGRC bulk expression cohort) [14–17] subclasses.
Signatures were determined using total lung mononuclear cell data from GSE132771 (Sheppard-UCSF single cell cohort) [19]. Cell cluster names follow labeling in S3A Fig. Labels used in S3 Fig are indicated in parentheses. A. Details of our workflow with datasets used at each step indicated. B. Gene signature scores for endothelial cell subpopulations. C. Gene signature scores for mesothelial cell populations. D. Gene signature scores for epithelial cell subpopulations. Adjusted p values are reported on plots.