Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Fig 6
Compound 3 plasma concentration inversely correlates with Th17 cytokine gene expression.
Th17 cytokine gene expression analysis was performed for Il17a (A) and Il17f (B) from IMQ-treated animals dosed with 6 or 60 mg/kg Compound 3. Gene expression is normalized to Gapdh and presented as fold change over naïve and plotted relative to plasma concentrations for Compound 3. Each symbol represents an individual animal and a linear regression (blue line) coefficient was calculated. Statistical significance (*p ≤ 0.05) was determined using linear regression analysis. Data are from a single experiment with n = 8/group.