Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Fig 2
Single molecule X-ray crystallography of Compound 3.
Small molecule X-ray structure of Compound 3 indicates only the (R,R)-enantiomer is present in the crystal structure. Crystal conformation of compound is and depicted in ball and stick representation (carbon–green; hydrogen–white; oxygen–red; nitrogen–blue; fluorine–magenta; chlorine–orange).