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Evaluation of CCL21 role in post-knee injury inflammation and early cartilage degeneration

Fig 5

IL-6 synthesis is induced in response to MMD at three days post-surgery.

Immunohistochemistry staining was performed using antibodies against rat IL-6 for both rat MMD- (A) and the left sham-operated knees (B) collected at day 3 post-surgery. Representative images of histology sections collected from rat MMD- (A) and sham-operated knees (B), brown color represents IL-6 positive areas. Arrows show some of IL-6 positive stained areas. The squares in the left panels represent the areas magnified 20x on the right panels. T. tibia plateau, F. femur condyles, ST, synovial tissue. MCL, medial collateral ligament. A and B were taken using 1.25x microscope lenses.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0247913.g005