Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis
Fig 5
A2 deletion protected against EAE-induced demyelination.
A-D) Representative images showing MBP staining. E-H) Higher magnification images from boxed areas showing the loss of myelin in WT EAE optic nerves while A2 deletion reduced the EAE-induced-demyelination. I) Quantification of immunofluorescence intensity of MBP. Number of animals used: 8(WT Control);12 (WT EAE); 9 (A2-/- EAE); 7 (A2-/- Control). Representative images are presented. Data are presented as mean ± SEM. #p<0.01 WT EAE vs WT Con and *p<0.05 A2-/- EAE vs WT EAE. Scale bar 50 μm.