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HPLC method development/validation and skin diffusion study of caffeine, methyl paraben and butyl paraben as skin–diffusing model drugs

Fig 5

Comparison between the chromatogram for the mixture of analytes (continuous line) and that of the matrix (dotted line).

The concentration of the mixture is 25 μg/mL with respect to each analyte.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0247879.g005