Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells
Fig 9
ANO2 in the olivo-cerebellar circuit.
Schematic illustration of a cerebellar module summarizing the recent findings about the role of ANO2 in the olivocerebellar cortex. Glutamatergic neurons are depicted in green and GABAergic neurons in red. ANO2 has been shown to be expressed in inferior olivary neurons, where it accelerates repolarization after high-threshold calcium spikes and, thus, promotes the generation of these calcium spikes [9]. In Purkinje cells, ANO2 attenuates excitability upon strong activation. First indications of an expression of ANO2 in neurons of the deep cerebellar nuclei is presented in Fig 1A, but functional involvement in the cerebellar module awaits investigation.