Hyper-connectivity between the left motor cortex and prefrontal cortex is associated with the severity of dysfunction of the descending pain modulatory system in fibromyalgia
Fig 3
Heatmap visualization of FC across regions of interest in Z-values.
Nonresponders presented higher connectivity than responders between LMC and bilateral PFC. Blue color edges represent significantly lower values and red color edges represent significantly higher values, relative to the comparison between groups. A. Mean FC by region of interest in CPM-test responders. B. Mean FC by region of interest in CPM-test nonresponders. FC: functional connectivity; CPM-test: conditioned pain modulation test. LPFC: Left prefrontal cortex; LMC: Left motor cortex; RPFC: Right prefrontal cortex; RMC: Right motor cortex. *p<0.05. † FC between regions of interest that were associated with CPM-test groups despite the interaction effect of multiple psychiatric diagnoses.