Pharmacokinetic profile of injectable tramadol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy
Fig 2
Median (with error) tramadol plasma concentrations vs. time curves when administered at 2 mg/kg, s.c. (n = 2) and 4 mg/kg, s.c. (n = 4).
Dotted line signifies suggested tramadol minimally effective plasma concentration in humans of 100 ng/mL [24]. The graph of the 4 mg/kg tramadol dose dips slightly below the 2 mg/kg tramadol dose–this may be due to individual variability between koalas.