Development and validation of a cellular host response test as an early diagnostic for sepsis
Fig 5
Trends in severity of illness across ISI interpretation bands for subjects in the high and low acuity cohorts, as measured by (A) SOFA, maximum over three days following ED presentation, (B) APACHE-II, (C) hospital free days for the subpopulation of subjects admitted to the hospital, (D) Admission to the ICU.
Hospital free days were defined as 28 days less the in-hospital length of stay, where in-hospital mortality leads to a value of zero. Box plots: lines in the boxes, medians; the box ends, interquartile ranges (IQR); whiskers, 1.5x IQR; diamonds, outliers. Bar graphs: Bars, percentages; error pars, 95% confidence intervals. p-values were obtained from an unpaired two-sample Welch’s t-test (except for hospital free days, where the Mann–Whitney U was due to the non-normal distribution), with the null hypothesis that the mean of the two samples are equal. p-values reported as * p < 0.05, ** p < 0.01, and *** p < 0.001.