The cost-effectiveness of prostate cancer screening using the Stockholm3 test
Fig 2
Schematic of the prostate cancer natural history model.
Individuals are assumed to be disease-free at age 35 years. They may progress to preclinical cancer states with a fixed Gleason score, with progression by T-stage and to metastatic cancer. Preclinical cancers may be diagnosed from nine different states, with survival from prostate cancer death evaluated from the possibly counterfactual time of clinical diagnosis. Death due to other causes is represented as a competing event.