Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
Fig 7
Schematic diagram of halogen bonding.
Halogen bonds exist between the halogen atom X (F, Cl, Br, or I) and the electron-rich δ– and/or electron-poor δ+ sites in the receptor protein. The electrons of atom X in the ligand molecule are maldistributed to the electron-rich δ– and electron-poor δ+ portions.