Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
Fig 6
Dehydrochlorination (–HCl) and hydrochlorination (+ HCl) between BPC and BPE-Cl (HPTE).
This chemical reaction formula is shown only for form’s sake. Synthesis of BPC by the dehydrochlorination of BPE-Cl (HPTE) was described by Cleveland et al. [39]. Ball and stick models are shown. The 3D-conformers of BPE-Cl [43] and BPC for this reaction formula were obtained from the chemical information resource PubChem [35].