Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
Fig 5
The bar chart diagrams of specific activities among halogen-containing bisphenols.
The activities of the bisphenols in the receptor-binding assays and luciferase reporter gene assays for ERα and ERβ were estimated by referring to the activity of BPE-Br as the standard (= 100). BPE-Cl is exactly the same compound as HPTE (see Fig 1).