Prediction of nasal spray drug absorption influenced by mucociliary clearance
Fig 5
Particle deposition patterns coloured by particle size ranging from 1μm to 150μm.
(a). Particle deposition distribution in 3D view of the right chamber. Nasal walls were set transparent to visualise particle deposition locations. (b). Particle distribution in the unwrapped 2D view. All deposited particles were at the right cavity where the spray particles were released. There are three hot-spots of deposition caused by direct impaction. The first hot-spot mainly depicted by large droplets with size >30μm was a band-like region that across vestibule and septum (① and ②), the second one is located at the tip of the middle turbinate (③) and the third one mainly hosts small droplets with size <30μm was a more concentrated area that across vestibule and lateral cavity (④). Another deposition hot-spot for nearly 30μm particles is located around the maxillary ostia (⑤).