Single nucleotide polymorphism leads to daptomycin resistance causing amino acid substitution—T345I in MprF of clinically isolated MRSA strains
Fig 5
(A) The concentration of bacteria was measured as the optical density at 660 nm. MprF mutant DAP resistant strain KAM18 and KAM17mut grew slower than DAP susceptible strains, KAM17 and KAM17mutR. The growth curves are representative of three independent experiments with similar results. (B) The doubling time of each strain was calculated according to its regression curve. The calculated values represent mean ± SD of three independent experiments (**p<0.01 vs. KAM17).