Human induced pluripotent stem cell-derived three-dimensional cardiomyocyte tissues ameliorate the rat ischemic myocardium by remodeling the extracellular matrix and cardiac protein phenotype
Fig 3
The three-dimensional human induced pluripotent cell-derived cardiac tissue (3D-hiPSC-CT) improved cardiac function in the myocardial infarction rat model.
(A–C) Results of B-mode echocardiogram: left ventricular ejection fraction (LVEF), end-diastolic diameter (LVDd), and end-systolic diameter (LVDs); *P < 0.01, ** P < 0.001. (D) Fibrosis area at the remote zone in myocardial infarction hearts 4 weeks after transplantation. Sections were assessed by Picro Sirius Red staining. * P < 0.01.