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Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression

Fig 6

Schematic representation of the findings described in this study.

SKO (PB-Cre4 PTEN^loxP/loxP) cancer cells do not metastasize and express low levels of αVβ3 integrin and high levels of αVβ6 integrin. On the other hand, DKO and TKO tumors (PB-Cre4 PTEN^loxP/loxP RB1^loxP/loxP and PB-Cre4 PTEN^loxP/loxP RB1^loxP/loxP TRP53^loxP/loxP respectively) express high levels of αVβ3 integrin and low levels of αVβ6 integrin. These αVβ3 positive tumors acquire metastatic behavior and expression of NE markers.

doi: https://doi.org/10.1371/journal.pone.0244985.g006