Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression
Fig 4
Increased expression of the αVβ3 integrin, but not αVβ6, correlates with the neuroendocrine marker SYP in LuCaP PDXs and human prostate tumor samples.
Immunohistochemical analysis of 42 LuCaP PDX models. (A) representative IHC staining for αVβ3 (left) or αVβ6 (right) integrin of SYP positive (top row) or SYP-negative (bottom row) LuCaP PDX models is shown. The bar at the bottom right corner of each panel represents 20 μm. (B) Heat map of the signature score for SYP, αVβ3 or αVβ6 integrin of each LuCaP is shown. Raw data are reported in the S1 Table. (C) Immunostaining analysis of αVβ3 and αVβ6 integrins and SYP primary tumors from ADPrCa patients. The bar at the bottom right corner of each panel represents 20 μm.