Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression
Fig 2
αVβ3 integrin is selectively upregulated in lung metastases of mice carrying neuroendocrine prostate cancer.
Immunostaining of the αVβ3 integrin (top panels), αVβ6 integrin (middle panels), and SYP (bottom panels) in the lung metastases from murine models with genetic knockdown of PTEN and RB1 (DKO; n = 5) and PTEN, RB1, and TRP53 (TKO; n = 5) in the prostatic epithelium. The bar at the bottom right corner of each panel represents 20 μm. First column: DKO; second column: TKO.