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Towards remote monitoring in pediatric care and clinical trials—Tolerability, repeatability and reference values of candidate digital endpoints derived from physical activity, heart rate and sleep in healthy children

Fig 3

Heart rate.

A: average (90% prediction interval) HR during daytime (blue). Average 95% CI nighttime HR (red). Reference values (10th– 90th percentile of HR per age year) are displayed in green. B: Average HR (95% CI) per hour of the day. C: estimated relationship between HR and step count for ages 2, 8, 12 and 16. A limited amount of age years is shown for readability.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0244877.g003