Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8
Fig 6
Schematic overview of pro- and anti-apoptotic proteins of the extrinsic apoptosis pathway identified in human platelets (right) in comparison with nucleated cells (left).
In nucleated cells, several death receptors are known, e.g. TNFRI/II, Fas/CD95, DR 1–5, which could not be yet identified in human platelets. Grey box: adaptor-proteins of the extrinsic apoptosis pathway identified by our group and others, e.g. TRADD, TRAF2/5, cIAP1/2, FADD, DJ-1, NEMO, IKK1/2, NFκB, and NFκB1.