Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales
Fig 5
Erysipelotrichales expansion is specific to NASH.
A) Relative abundance of specific taxa over 12 weeks. B) Erysipelotrichales bacteria expand in NASH but not other conditions whereas C & D) decreased abundance of Verrucomicrobiales and Bacteroidales is observed in both WD-only and NASH. Fecal samples sequenced from 3–10 mice per condition (mean = 5), except NASH week 12 where n = 2. P values are encoded as * = p < 0.05, ** = p < 0.01, and *** = p < 0.001.