Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the nervous tissue
Fig 2
C57BL/6 mice infected with the Colombian Trypanosoma cruzi strain control parasitemia, survive, and develop chronic phase with preserved muscle strength.
(A) Mice were infected with 100 blood trypomastigote forms, parasitemia and death were recorded weekly, and the animals were analyzed in the chronic phase of infection (120 dpi). (B) Survival curve (percentage of alive mice). (C) Parasitemia curve (Parasites x 104/mL). (D) The graph shows the results of muscle strength [gram force (gf)/body weight (g)] of T. cruzi-infected mice compared with sex- and age-matched noninfected controls (NI), at 120 dpi. Each experimental group consisted of 5 NI mice and 7–10 T. cruzi-infected mice. Each circle represents an individual mouse. Data are represented as means ± SE of three independent experiments (15 NI; 27 T. cruzi-infected mice). Data were analyzed using t-Student test.