The mitochondria-targeted derivative of the classical uncoupler of oxidative phosphorylation carbonyl cyanide m-chlorophenylhydrazone is an effective mitochondrial recoupler
Fig 5
A. Dose dependence of respiratory stimulation by mitoCCCP with succinate as a substrate of mitochondria. Shown are Mean±S.D. (n = 4). For experimental conditions, see Materials and methods. B. Effect of mitoCCCP on the mitochondrial membrane potential in rat liver mitochondria (RLM) estimated by measuring absorbance changes of the potential-sensitive dye safranine O (15 μM). For experimental conditions, see Materials and methods. Insert: dose dependence of the effect of mitoCCCP on the membrane potential of RLM (Mean±S.D., n = 3).