A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates
Fig 2
Dates of licensure under RCT, ORCT, ARCT, HCT (30-day set-up time), and HCT (90-day set-up time), assuming superiority testing, a vaccine efficacy of 50%, and a population vaccination schedule of 10M doses per day.
(a) Under the behavioral epidemiological model. (b) Under the status quo epidemiological model.