The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice
Fig 5
CU06-1004 reduces LSEC capillarization in mice with CDAA diet-induced NASH.
(A and C) Immunohistochemical analysis of ICAM-1 and CD31 in liver and (B and D) quantification of the stain-positive area. (E-H) Quantitative polymerase chain reaction (qPCR) analysis of mRNA expression in liver of genes involved in endothelial adhesion molecules-related genes. Data are presented as the mean ± SEM. # p < 0.05 vs. control group; * p < 0.05 vs. CDAA alone group; n = 5 mice/group (A-D); n = 9 mice/group (E-H).