IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations
Fig 5
IL-17C contributes to acute COPD-like lung inflammation.
WT and Il-17c-/- mice were exposed to NTHi (day 1, 3, and 5) or the combination of NTHi (day 1, 3, 5) and CS (day 1 to 5). Numbers of total immune cells (A), neutrophils (B), macrophages (C), and lymphocytes (D) were determined in BAL fluids 24 hours after the final exposure to NTHi (n = 7 per group). Concentrations G-CSF (E), MIP-2 (F), and KC (G) were measured in lung homogenate (n = 4–7 mice per group). Data were compared by One-way ANOVA with Bonferroni post-test and are shown as the mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001.