Transcriptional insights into pathogenesis of cutaneous systemic sclerosis using pathway driven meta-analysis assisted by machine learning methods
Fig 6
Hub-gene centered subnetwork based on random walk and neighborhood scoring algorithms.
(A) TLR7 centered subnetwork identified by random walk algorithm and MRSS correlations. (B) IRAK2 centered subnetwork identified by neighborhood scoring algorithm and MRSS correlations. (C) FGFR1 centered subnetwork identified by random walk algorithm and MRSS correlations. In all 3 subnetworks, hub gene regulators are highlighted in blue and the edge of inhibiting relationships between two genes are colored in light blue as well.