Transcriptional insights into pathogenesis of cutaneous systemic sclerosis using pathway driven meta-analysis assisted by machine learning methods
Fig 5
The Pearson correlation scatter plot of selected gene regulators showing significantly positive association between normalized gene expression and MRSS.
The 9 genes (CCL2, COL1A1, FGFR1, FN1, IGF1, IL6, IRAK2, MMP1, TLR7) shown in the figure were selected from random walk or neighborhood scoring algorithm, and are positively correlated with MRSS based on study GSE58095. These 9 genes are mostly expressed on myeloid / stromal cells and many of them are deeply involved in cell skeleton remodeling, innate immune response and cell-cell adhesion processes.