Identifying transcriptomic correlates of histology using deep learning
Fig 5
Visualizations of select histological features.
The following features (of the form [layer]_[channel]) found correlated with specific genes are visualized on each row: row 1: 22_405 NKX2-1 (r = 0.726) Thyroid GTEX-11NSD-0126_31_16, row 2: 27_343 TG (r = 0.801) Thyroid GTEX-11NSD-0126_31_16, row 3: 29_499 PAX8 (r = 0.802) Thyroid GTEX-11NSD-0126_31_16, row 4: 25_260 NEB (r = 0.831) Muscle—Skeletal GTEX-145ME-2026_39_19. Original image (column 1), guided backpropagation of the feature on the original image (column 2), synthetic image of the feature (column 3), immunohistochemistry image for the corresponding gene from the Human Protein Atlas (column 4).