Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia
Fig 2
Elevated numbers of rods with swollen mitochondria in Chmnull/WT.
Eyes from 6-month-old heterozygous null female mice (Chmnull/WT) were processed for transmission electron microscopy. (A) Analysis along the full length of the retina (from peripheral through central to peripheral) revealed occasional cells with swollen mitochondria and degenerating outer segments (OS) in both Chmnull/WT and controls. Scale bars: 1μm. (B) Quantitative analysis revealed a greater number of such cells in Chmnull/WT. T test: **p<0.01, n = 8.