Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI
Fig 9
Correlation between water Apparent Diffusion Coefficient (ADC) and cell density (DAPI).
Control tumors had a constant diffusion over the course of tumor progression and cell growth, while MCT mice had greater diffusion with cell death (lower cell densities in both core and rim). Ki67, a cell proliferative marker, densities are corresponding with control (blue) and MCT (red) mice in the core and periphery of 4T1 tumors. Tumor cores did not vary between the treated and untreated groups. However, the rim of the MCT mice had significantly more Ki67.