Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action
Fig 2
Statistical analysis produced with metabolomics data.
(A) PCA (principal component analysis) does not consider differences between active and inactive samples to group them, (Fig B) PLS-DA (partial least squares discriminant analysis) considers the difference and maximizes it, (C) PCA–loading, and (D) VIP (Variable importance projection) scores show the different important ions presented in the chemical profile of 9 different C. suberosus extracts used to create active and inactive groups, both pinpointing ion m/z 391.2284 as important for differentiation, and associated L. amazonensis promastigote mortality.