In situ evaluation of podocytes in patients with focal segmental glomerulosclerosis and minimal change disease
Fig 2
Evidence of podocyte autophagy in renal biopsy of patients with FSGS and MCD.
(A) Density of LC3-labeled podocytes in three groups. ANOVA test followed by Tukey’s multiple comparison test. The bars represent the mean and the vertical lines represent the standard error of the mean. (B) LC3-labeled podocytes in the control, FSGS, and MCD groups (arrows). (C) Difference in the number of autophagosomes between control, FSGS and MCD groups implies higher autophagy in MCD and control group. ANOVA test followed by Tukey’s multiple comparison test. Bars represent the mean and vertical lines represent standard error of the mean. (D) TEM showing autophagosomes characterized as a multivesicle bodies containing undigested cytoplasmic material in podocytes (arrows) and pedicels (arrow head). Δ: Significant difference between FSGS and control group. Φ: Significant difference between FSGS and MCD group.