Chest computed tomography outcomes in a randomized clinical trial in cystic fibrosis: Lessons learned from the first ataluren phase 3 study
Fig 2
Stacked bar plots showing the wide spectrum of disease scores found by the CF-CT (A) and PRAGMA-CF scoring system (B). A. This stacked bar plot shows the distribution of the CF-CT %total score scores at start of study (SOS) for 195 patients. Patients are sorted based on the CF-CT %total score. %total score for each patient is subdivided by the subscores %Bronchiectasis, %Mucus Plugging, %Airway Wall Thickening and %Atelectasis. Note the wide distribution of %total score ranging from 0 to 37%. B. This stacked bar plot shows the distribution of the % volume of the lung at start of study (SOS) for 195 patients occupied by structural lung abnormalities as determined by PRAGMA-CF score. Patients are sorted based on the PRAGMA-CF %Disease subscore which is the sum of PRAGMA-CF %Bronchiectasis, %Mucus Plugging, and %Airway Wall Thickening. %Atelectasis (is depicted on top of %disease). Note the wide distribution of %Disease severities ranging from 0 to 35.5%.