LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production
Fig 5
LPCAT1 expression regulates paclitaxel sensitivity.
(A): Cell viability was determined in LPCAT1 and control groups with the increasing concentration of paclitaxel treatment (1, 10 and 100 nM). (B): Cell apoptosis in LPCAT1 and control groups with paclitaxel (10 nM) treatment. (C) and (D): Cells were injected into 6 nude mice to initiate tumorigenesis, with paclitaxel treatment administered 14 days post inoculation. Tumor volumes at different time points (C) and tumors weights (D) at excision. Values are presented as mean ± s.e.m. * P < 0.05 and ** P < 0.01 compared with control.