Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
Fig 6
Synergistic effects on apoptosis induction were observed by T3 in combination with Bcl-2 inhibitor in HCT116 and A2780 cells.
HCT116 and A2780 cells were treated with T3 or T3-1 and ABT-263 at the indicated concentrations for 16 h or 24 h, respectively. Caspase 3/7 activities were measured. Combination index (CI) values [24] are shown above the bar. A CI value of < 1 indicates synergism. Data are presented as the mean ± SD of two independent experiments.