Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils
Fig 2
Analysis of Aβ(1–40) peptides in bicine and PBS via (a) structural analysis by CD spectra and (b) TEM imaging. (a) Aβ(1–40) (25 μM) peptides were dissolved and incubated in bicine (20 mM) for 2 days or PBS (1X) for 0 and 2 days. (b) Aβ(1−40) (50 μM) incubated for 2 days in bicine (20 mM) and PBS. TEM imagery scale bar indicates 100 nm of size. These experiments were performed in triplicate independently. CD: circular dichroism, TEM: transmission electron microscopy, d: day.