Detecting inversions with PCA in the presence of population structure
Fig 2
Analysis of chromosome arms without known major inversions (Drosophila 3L—6 samples with inversion excluded (see Methods), 150 Anopheles 3L, and 34 Anopheles 3L). (a—c) PCA of samples, clustered with k-means, and colored by cluster. Manhattan plots visualizing p-values from association tests against sample cluster IDs (d—f) and PC coordinates (g—l, one Manhattan plot per PC).