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In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm

Fig 5

Key interactors in the predicted mechanism of action of pirfenidone and melatonin combination over the ARD set.

Only the most relevant ARD effectors appear in the figure, represented as octagons.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0240149.g005