Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology
Fig 2
Pathology in the traditional versus modified DMM model of OA.
Adult male C57BL/6 mice underwent either traditional destabilisation of the medial meniscus (DMM) (n = 7) or sham surgery (n = 6) (A, B, C, D). Cartilage damage (A) and synovitis (B) were analysed 16 weeks post-surgery. Representative images of sham (C) and traditional DMM (D) joints. Adult male C57BL/6 mice underwent either modified destabilisation of the medial meniscus (DMM) (n = 8) or sham surgery (n = 8) (E, F, G, H). Cartilage damage (E) and synovitis (F) were analysed 16 weeks post-surgery. Representative images of sham (G) and modified DMM (H) joints. Data analysed by Mann Whitney U-Test ** = p<0.01 DMM vs Sham.