Mining a human transcriptome database for chemical modulators of NRF2
Fig 7
NRF2 activity of selected chemicals in HepG2 cells.
Thirty chemicals tested for confirmation in the SRXN1-GFP assay. Cells were treated at multiple concentrations and examined for GFP accumulation over a 24-h period (GFP_pos_1–10) for concentrations 1 to 10. The last two columns, PI_pos_10 and cell_count_10, are the Propidium Iodide positive fraction of cells (marker for necrosis/ dead cells) and cell count compared to the negative control, respectively.