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Modeling of paclitaxel biosynthesis elicitation in Corylus avellana cell culture using adaptive neuro-fuzzy inference system-genetic algorithm (ANFIS-GA) and multiple regression methods

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Paclitaxel biosynthesis in Corylus avellana cell suspension culture (CSC) exposed to optimized fungal elicitor and methyl-β–cyclodextrin concentration levels, fungal elicitor adding day and CSC harvesting time in adaptive neuro-fuzzy inference system (ANFIS) models using genetic algorithm (GA), and predicted paclitaxel biosynthesis via ANFIS-GA.

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doi: https://doi.org/10.1371/journal.pone.0237478.t003