Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling
Fig 1
The structure of the KDM2A and KDM2B proteins and mRNAs.
A. The protein structure of KDM2A and KDM2B is very similar. They contain the N-terminal Jumonji-C demethylase domain (JmjC), the DNA binding domain (CXXC), the zinc finger PHD domain (PHD), the F-box domain (F-box), and the C-terminal leucine rich repeats domain (LRR). The KDM2A proteins contain also the HP1a interaction motif (in red). B. The exon structures of the KDM2A and KDM2B genes are also very similar. The full length KDM2A and KDM2B mRNA isoforms contain 21 and 23 exons, respectively, and the transcription of both KDM2A-SF and KDM2B-SF mRNAs starts in the 12th intron of the KDM2A and KDM2B genes, respectively.