Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry
Fig 2
Full scan chromatograms and extracted ion chromatograms [M+H]+ of gefitinib and its tentative metabolites in human plasma.
Line chart in green: Sample group. Plasma collected after oral administration of gefitinib. Line chart in blue: Control group. Plasma collected before oral administration of gefitinib. The parent drug and 18 tentative metabolites were discovered by comparing sample group with control group and are labeled in order of retention time.