Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ
Fig 7
The ROMK-selective blocker TPN-LQ showed similar behavioral effects.
(A) TPN-RQ blocked ROMK, GIRK1/2, and GIRK1/4 channels nearly equally. (B) TPN-LQ blocked ROMK channel selectively over GIRK1/2 and GIRK1/4 channels. TPN-LQ decreased immobile time in the TST (C) and the FST (D) at the same dose as TPN-RQ. TPN-LQ showed the anxiogenic effect in EPM (E) and OFT (F). TPN-LQ decreased spontaneous rotations in the activity wheel, indicating the impairment of locomotor activity (G). Another ROMK selective blocker, VU591, also showed antidepressive effect in the TST (H).